Comparison of computed tomography perfusion and magnetic resonance imaging perfusion-diffusion mismatch in ischemic stroke

BCV Campbell; S Christensen; CR Levi; PM Desmond; GA Donnan; SM Davis; MW Parsons

Journal article

Comparison of computed tomography perfusion and magnetic resonance imaging perfusion-diffusion mismatch in ischemic stroke

BCV Campbell, S Christensen, CR Levi, PM Desmond, GA Donnan, SM Davis, MW Parsons

Stroke | Published : 2012

DOI: 10.1161/STROKEAHA.112.660548

Abstract

BACKGROUND AND PURPOSE-: Perfusion imaging has the potential to select patients most likely to respond to thrombolysis. We tested the correspondence of computed tomography perfusion (CTP)-derived mismatch with contemporaneous perfusion-diffusion magnetic resonance imaging (MRI). METHODS-: Acute ischemic stroke patients 3 to 6 hours after onset had CTP and perfusion-diffusion MRI within 1 hour, before thrombolysis. Relative cerebral blood flow (relCBF) and time to peak of the deconvolved tissue residue function (Tmax) were calculated. The diffusion lesion (diffusion-weighted imaging) was registered to the CTP slabs and manually outlined to its maximal visual extent. Volumetric accuracy of CT-..

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University of Melbourne Researchers

Bruce Campbell Author

Patricia Desmond Author

Geoffrey Donnan Author

Stephen Davis Author

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia

Awarded by Australian Research Council Fellowship

Awarded by Australian Research Council

Funding Acknowledgements

Dr Campbell receives research support from the National Health and Medical Research Council (NHMRC) of Australia (postgraduate scholarship 567156, early career fellowship 1035688), the Heart Foundation of Australia, a Cardiovascular Lipid (CVL) Australia grant, and the Neuroscience Foundation of the Royal Melbourne Hospital. Dr Parsons receives research support from an Australian Research Council Fellowship FT0991128, the NHMRC, and the National Stroke Foundation. Infrastructure support was received for these studies through the Victorian Government Operational Infrastructure Program to the Florey Neuroscience Institutes.